Fig. 1: Amantadine among other inhibitors blocks the ion channel function of SARS-CoV-2 Protein E.
From: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro
a Summarized and averaged I/V relations in SARS-CoV-2 Protein E-expressing oocytes revealed significantly different current activity compared to control (uninjected) oocytes. The current activity at −85 mV in SARS-CoV-2 Protein E-expressing oocytes normalized to that of uninjected oocytes. b–i Eight compounds (10 μM) were tested on SARS-CoV-2 Protein E activity. Amantadine (b), HMA (e), emodin (f), and xanthene (g) blocked the activity, whereas no inhibition of SARS-CoV-2 Protein E by rimantadine (c), adamantane (d), pyronin B (h), or pyronin Y (i) was observed. b–i current activity at −85 mV with the treatment of the specific drugs normalized to the current activity obtained without treatment. Statistical significance was determined with unpaired Student t test, **P < 0.01; ***P < 0.001, of n = 4 biologically independent experiments.
