Fig. 5: All four viroporins of SARS-CoV-2 can be blocked by drugs.
From: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro
a Protein 3a-, b ORF7b-, and c ORF10-mediated current activity was monitored in the absence and presence of selected drugs (10 µM). Amantadine was ineffective on Protein 3a (a) and ORF7b (b), but blocked the activity of ORF10 (c). Xanthene blocked the activity of both Protein 3a (a) and ORF7b (b), while emodin blocked ORF7b (c). a–c Current activity at −85 mV with the treatment of the specific drugs normalized to the current activity obtained without treatment. Statistical significance was determined with unpaired Student t test, **P < 0.01; ***P < 0.001, of n = 3 biologically independent experiments.
