Fig. 1: The overall structure of hMETTL6.
From: Crystal structure of human METTL6, the m3C methyltransferase
a The chemical reaction that hMETTL6 catalyzes and its structural basis. Left: the structure was shown in cartoon in two orthogonal views and the SAH ligand was shown as sticks. The N- and C-termini were indicated, and the helices were labeled. Right: the chemical reaction carried out by the METTL2/6/8 enzymes. b Multiple sequence alignment of hMETTL6 with orthologs and other published structures. The secondary structure elements were labeled above the sequences. The key residues for SAH contacts were indicated by the red arrows. The magenta boxes indicated the residues important for SAH binding, whereas blue boxes indicated the residues important for CMP binding.
