Fig. 6: The binary model of the hMETTL6-tRNA complex.
From: Crystal structure of human METTL6, the m3C methyltransferase
Top panel: the superimposition of hMETTL6 with that of the PaTrm5a-PatRNAPhe-SAH complex in the front and back views (PDB 5WT1). The blue molecule on the top right corner represents the yeast tRNAPhe molecule (SctRNAPhe) with a classical conformation (PDB 6TNA). Bottom panel: the close views of the anticodon loop interactions with the hMETTL6-SAH complex (left) and the comparison of these regions from two tRNA molecules (right). The red arrow indicated the rotation of the anticodon loop needed for the methylation. The bases at positions of 32 and 37 were shown. Note that the bases of SctRNAPhe were modified. OMC: 2′-O methylcytosine; YG: wybutosine. The coloring of the molecules corresponded to their names.
