Fig. 4: Representation of water molecules in the binding pocket of streptavidin structures.
From: Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature

a Apo-SFX structure and b Apo-Cryo structure of apo-state streptavidin and c Holo-SFX structure with selenobiotin (BTN) (PDB ID: 5JD2) are shown with their surface and water molecules are shown with red spheres. The indicated residues around the binding pocket are shown in orange color.