Table 2 Fecal metabolite clusters significantly altered (FDR < 0.05) in Mecp2-e1−/+ vs. Mecp2-e1 + /+ females.
Cluster name | Num. analytes/ cluster | p-value | FDR | Key compound | Num. altered metabolites | Num. increased | Num. decreased |
|---|---|---|---|---|---|---|---|
Unsaturated triglycerides | 39 | 1.5E-16 | 3.7E-15 | Triglyceride 52:1 | 26 | 8 | 18 |
Dipeptides | 4 | 2.9E-08 | 2.3E-07 | Ala-Ala | 4 | 3 | 1 |
Phosphatidylcholines | 26 | 3.4E-08 | 2.3E-07 | Phosphatidylcholine 32:0 | 10 | 5 | 5 |
Amino acids, basic | 5 | 3.8E-08 | 2.3E-07 | N-Methyltyrosine | 5 | 4 | 1 |
Unsaturated fatty acids | 24 | 0.000036 | 0.00017 | Fatty Acid 18:2 | 10 | 5 | 5 |
Indoles | 3 | 0.0001 | 0.0004 | N-.alpha.-Acetyl-L-arginine | 3 | 1 | 2 |
Azoles | 3 | 0.00015 | 0.0005 | Creatinine | 2 | 2 | 0 |
Phosphatidylethanolamines | 8 | 0.00034 | 0.001 | Phosphatidylethanolamine 34:1 | 3 | 2 | 1 |
Pyridines | 8 | 0.00084 | 0.0022 | 3-Aminopyridine | 4 | 4 | 0 |
Carnitines | 5 | 0.0013 | 0.0031 | 3-Dehydrocarnitine | 3 | 3 | 0 |
Unsaturated ceramides | 8 | 0.0023 | 0.005 | Ceramide d39:1 | 5 | 1 | 4 |
Saturated triglycerides | 3 | 0.0025 | 0.005 | Triglyceride 46:0 | 3 | 0 | 3 |
Amino acids | 5 | 0.0047 | 0.0087 | Isoleucine | 3 | 3 | 0 |
Diglycerides | 8 | 0.021 | 0.037 | Diglyceride 38:5 | 4 | 3 | 1 |
Saturated FA | 18 | 0.031 | 0.05 | Fatty Acid 20:0 | 3 | 3 | 0 |
