Fig. 2: Activity and expression of MARK3 are suppressed by genomic and epigenetic alterations. | Communications Biology

Fig. 2: Activity and expression of MARK3 are suppressed by genomic and epigenetic alterations.

From: The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma

Fig. 2

a Pie charts show putative copy number alteration (CNA) profiles of MARK3, MAF, and BNC1. b CNA and mRNA expression levels of MARK3, MAF, and BNC1 are plotted using the TCGA HGSOC data set (n = 489). Each sample was segregated according to their CNA status: amplification (CNA = +2); gain (CNA = +1); duplicate (CNA = 0); deletion (CNA = −1); deep deletion (CNA = −2). Error bars represent mean ± standard deviation (SD). Statistical analysis was performed using one-way ANOVA. c Pie charts show putative CNA profiles of LKB1, TAOK1, and PIM1. d CNA and mRNA expression levels of LKB1, TAOK1, and PIM1 are plotted using the TCGA HGSOC data set (n = 489). Error bars represent mean ± SD. Statistical analysis was performed using one-way ANOVA. e Schematic of the 3555-kb long genomic region around MARK3 loci in chromosome 14q32.33. f Relative linear copy number values of MARK3 are plotted against those of HSP90AA1 and AKT1 (n = 489). The data were analyzed using Pearson’s correlation coefficients. g mRNA expression levels of MARK3 are plotted against those of HSP90AA1 and AKT1 (n = 489). The data were analyzed using Pearson’s correlation coefficients.

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