Fig. 4: Integrative understanding of Alu-associated molecular processes in glioma.

a Average fold change of mRNA expression levels of A-to-I editing enzyme ADAR families (ADAR1, ADAR2, and ADAR3). Statistical significance of differential expression was determined by a R package DESeq2: significant if FDR-adjusted p value < 0.05 (N = 12, 18, 8, 10, 4, 30 tissues for O2, O3, A2, A3, A4, GBM, respectively). b Venn diagram of the genes with differentially-edited A-to-I editing sites and the genes showing differential expression rates of circular RNA. c The distributions of A-to-I editing level changes in tumors relative to matched normal tissues were compared between the two gene groups made by whether genes show the decreased circular RNA expression rates in tumors relative to matched normal tissues (two-sided Kolmogorov-Smirnov test p value: 0.07202, N = 1578 A-to-I editing sites). d Gene ontology terms that were enriched with the genes whose gene bodies harbor the differentially-edited A-to-I editing sites between tumor and matched normal tissues. The terms found in at least two pathologies of glioma were shown.