Fig. 2: Visual plasticity is reduced at early stages of tauopathy.
From: Plasticity in visual cortex is disrupted in a mouse model of tauopathy
a Mice (5 months old) were exposed to a grating of one orientation (either 45° or −45°; ‘familiar’ stimulus) for 9 days. On the first and last day of recordings, five blocks of this familiar stimulus were interleaved with five blocks of a grating (‘unfamiliar’) whose orientation was orthogonal to the familiar grating. On days 2–8, 10 blocks of the familiar stimulus were presented. b Change in the VEP amplitude from day 1 (VEP amplitude on each day, minus the VEP amplitude on day 1, calculated separately for each animal before averaging) for the familiar stimulus, for Tau− (blue) and Tau+ (red) animals. Tau+ mice showed a slower potentiation of the LFP signal compared to Tau− animals. Shaded area represents the mean ± SEM (n = 12 Tau−, n = 11 Tau+). The asterisk denotes significance between the two groups on the respective day. The open symbols on the right show the change in VEP amplitude in response to the unfamiliar stimulus on day 9, compared to day 1. c–e Comparison of average VEPs (top) and VEP amplitudes (bottom) between: days 1 vs 3 for the familiar stimulus (c), days 1 vs 9 for the familiar stimulus (d), and days 1 vs 9 for the unfamiliar stimulus (e). ****p < 10−4, ***p < 10−3, *p < 0.05. The source data underlying this figure are available in Supplementary Data 2.
