Fig. 3: Visual plasticity diminishes with age.
From: Plasticity in visual cortex is disrupted in a mouse model of tauopathy
a Mice (8 months old) were exposed to a grating of one orientation (either 45° or −45°; ‘familiar’ stimulus) for 9 days (same as in Fig. 2a). b Difference in the VEP amplitude from day 1 for the familiar stimulus for Tau− (blue) and Tau+ (red) animals over the course of days. 8-month old Tau− mice showed a smaller potentiation of the LFP signal compared to 5-month old mice (Fig. 2b). Tau+ mice showed no potentiation. Shaded area represents the mean±SEM (n = 13 Tau−, n = 13 Tau+). The open symbols on the right show the change in VEP amplitude in response to the unfamiliar stimulus on day 9. c, d Comparison of average VEPs (top) and VEP amplitudes (bottom) between: days 1 vs 9 for the familiar stimulus (c), and days 1 vs 9 for the unfamiliar stimulus (d). The source data underlying this figure are available in Supplementary Data 3.
