Fig. 5: Differences in visual plasticity are not due to differences in behavioural state.
From: Plasticity in visual cortex is disrupted in a mouse model of tauopathy
a VEP responses on day 1 for Tau− (blue, n = 12) and Tau+ (red, n = 11) 5-month old animals calculated during running (speed > 1 cm/s) and stationary epochs. Running reduces the VEP signal for both groups of mice. b VEP amplitude during stationary versus running epochs for individual Tau− (blue circles) and Tau+ (red triangles) mice. Each symbol represents the VEP amplitude on one day in one animal. c Difference in the VEP amplitude from day 1 for the familiar stimulus, for Tau− and Tau+ 5-month old animals, calculated for only stationary (left) or only running (right) epochs. VEP potentiation was evident in both groups of animals for both behavioural states. Shaded area represents the mean ± SEM (n = 12 Tau−, n = 11 Tau+). **p < 0.01, *p < 0.05. d We fitted an elastic net regularisation model to predict the VEP amplitude for each animal using days, block number, movement speed, and pupil diameter as regressors. We assessed the impact of each regressor in predicting the VEP amplitude as the product between each learned weight and observed variable, divided by the predicted value across the entire regularisation path (of elastic net regression). The panel shows the average regressor impact for each phenotype at 5 and 8 months of age. The source data underlying this figure are available in Supplementary Data 5.
