Fig. 3: Development of HCC suppressed by the hepatocyte-specific deletion of Dll4. | Communications Biology

Fig. 3: Development of HCC suppressed by the hepatocyte-specific deletion of Dll4.

From: Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice

Fig. 3

a Representative macroscopic pictures of liver tumors observed in DEN-treated male control or hepatocyte-specific Dll4 knockout mice (Dll4-HepKO). Arrows indicate the tumors observed on the liver surface. The histograms show the incidence of development of tumors (b), the mean number of tumors (c), and the average size of tumors (d) observed in the control (Cont) and Dll4-HepKO (KO) mice. The values represent the mean ± SD in 11 samples from the control mice and nine samples from the Dll4-HepKO mice. e Excised HCC specimens were subjected to immunofluorescent co-staining using antibodies against Hes1 (green), NICD1 (magenta), and Hnf4α (blue). The border between HCC and non-tumorous tissue is indicated by a hatched line. Scale bar, 50 μm.

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