Fig. 4: Development of HCC induced by the deletion of Jag1. | Communications Biology

Fig. 4: Development of HCC induced by the deletion of Jag1.

From: Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice

Fig. 4

a Representative macroscopic pictures of liver tumors observed in DEN-treated male control or Jag1 conditional knockout mice (Jag1-MxKO). Arrows indicate the tumors observed on the liver surface. The histograms show the incidence of development of tumors (b), the mean number of tumors (c), and the average size of tumors (d) observed in the control and Jag1-MxKO male and female mice. The values represent the mean ± SD from the control (42 males and 19 females) and Jag1-MxKO (15 males and 11 females) mice. e Excised HCC specimens were subjected to immunofluorescent co-staining using anti-Hes1 (green) and anti-Jag1 antibodies (magenta) together with DAPI nuclear staining (blue). Scale bar, 100 μm.

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