Fig. 9: Neuroprotective effects of VK-B2R interaction in cerebral ischemia.
From: Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice
Targeting the VK–B2R interaction promotes functional recovery in mice after ischemia stroke, including an improvement of neurological impairment, reduction of infarct volume, maintenance of blood-brain barrier integrity, and an obstruction of the inflammatory response and oxidative stress. VK treatment led to reduced neuroinflammation and apoptosis associated with the activation of PI3K–AKT and inhibition of IκBα–NF-κB signaling pathways.
