Fig. 1: Proposed model for CCM in S. oneidensis.
From: NapB Restores cytochrome c biosynthesis in bacterial dsbD-deficient mutants
The model illustrates oxidation and reduction of apocyts c. In S. oneidensis, a large majority of apocyts c can be oxidized by DsbA proteins and by oxidative agents (OAs). These oxidized apocyts c rely on reducing equivalents from DsbD via CcmG and CcmH for their reduction such that covalent heme ligation could occur on CcmF. A residual quantity of reduced apocyts c (red dash line) can be matured by the CCM system without needing electrons from DsbD. In the absence of DsbD, NapB can donate electrons to CcmG for reduction of the oxidized apocyts c. Reducing agents (RAs) may prevent oxidation of apocyts c (red dash line) or reduce oxidized apocyts c (red solid line). RAs may also donate electrons to CcmH and/or NapB (dark green dash lines). Q quinol species, SP signal peptide, OPs other processes.
