Fig. 4: Nine proteins relevant to inflammation, transcription regulation, and metabolism are significantly increased in post-mortem autopsy brains of human sporadic Alzheimer’s disease. | Communications Biology

Fig. 4: Nine proteins relevant to inflammation, transcription regulation, and metabolism are significantly increased in post-mortem autopsy brains of human sporadic Alzheimer’s disease.

From: Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity

Fig. 4

a, b. Western blot and quantifications showing significantly elevated levels of predicted proteins relevant to inflammatory pathways (PIBF1, CRTAM, FRRS1, and LILRA3), transcriptional regulation (FOXP4 and SPOP), metabolism (PIBF1 and STARD3), and others (TXNDC12 and FAM92B) in post-mortem temporal cortical samples of sporadic AD compared to age-matched healthy controls (HC). Note that SCGB3A1 and SLC44A2 were not detectable. Individual gels are separated and aligned with their corresponding loading control (GAPDH). The middle gel was stripped and reprobed accordingly. (Raw blots are shown in Supplementary Fig. 10). Data shown are mean ± s.e.m of ratio to consecutive loading control GAPDH; significance was determined using two-tailed t tests Welch-corrected; *p < 0.05; **p < 0.01, (P values for FRRS1 = 0.0340, STARD3 = 0.0176, PIBF1 = 0.0363, TXNDC12 = 0.0122, FAM92B = 0.0456, FOXP4 = 0.0474, SPOP = 0.0183, CRTAM = < 0.0001, and LILRA3 = 0.0392) n = 7 healthy controls and n = 8 sporadic AD).

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