Table 1 Summary of statistically enriched genes identified in compound selections.
Gene | Description | NG | NC | Compounds | p-value |
|---|---|---|---|---|---|
YRM1 | Zn2-Cys6 zinc-finger transcription factor | 52 | 13 | See Supplementary Data 4 | 3.53 × 10−116 |
YRR1 | Zn2-Cys6 zinc-finger transcription factor | 48 | 12 | See Supplementary Data 4 | 2.51 × 10−105 |
PMA1 | Plasma membrane P2-type H + -ATPase | 15 | 5 | GNF-Pf-445, Hygromycin B, KAE609, Wortmannin, GNF-Pf-3891 | 3.00 × 10−24 |
BUL1 | Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex | 14 | 11 | See Supplementary Data 4 | 3.92 × 10−22 |
PDE2 | High-affinity cyclic AMP phosphodiesterase | 13 | 2 | MMV000570, MMV007181 | 4.76 × 10−20 |
TPO1 | Polyamine transporter of the major facilitator superfamily | 12 | 5 | GNF-Pf-4283, MMV006389, CBR410, CBR572, TCMDC-124263 | 5.34 × 10−18 |
ANY1 | Putative protein of unknown function | 11 | 5 | Amitriptyline, MMV019017, Clomipramine, MMV396736, Sertraline | 5.51 × 10−16 |
BAP2 | High-affinity leucine permease | 10 | 6 | GNF-Pf-3703, GNF-Pf-3815, GNF-Pf-5129, GNF-Pf-5468, MMV006389 | 5.19 × 10−14 |
SIP3 | Putative sterol transfer protein | 8 | 3 | GNF-Pf-445, Lomerizine, Loratidine | 3.38 × 10−10 |
INP53 | Polyphosphatidylinositol phosphatase | 8 | 1 | MMV000442 | 3.38 × 10−10 |
AFT1 | Transcription factor involved in iron utilization | 7 | 3 | MMV085203, MMV1007245, CBR868 | 2.28 × 10−8 |
PDR1 | Transcription factor that regulates the pleiotropic drug response | 7 | 7 | DDD01027481, Doxorubicin, MMV000442, MMV007224, MMV667491, CBR668, CBR110 | 2.28 × 10−8 |
ERG9 | Farnesyl-diphosphate farnesyl transferase | 7 | 2 | AN7973, MMV1078458 | 2.28 × 10−8 |
YAP1 | Basic leucine zipper (bZIP) transcription factor | 6 | 4 | Cycloheximide, GNF-Pf-4739, DDD01027481, MMV001246 | 1.34 × 10−6 |
TOP2 | Topoisomerase II | 6 | 1 | Etoposide | 1.34 × 10−6 |
HXT3 | Low-affinity glucose transporter of the major facilitator superfamily | 6 | 3 | Amitriptyline, DDD01035522, GNF-Pf-445 | 1.34 × 10−6 |
ERG11 | Lanosterol 14-alpha-demethylase | 6 | 2 | MMV001239, CBR499 | 1.34 × 10−6 |
FUR1 | Uracil phosphoribosyltransferase | 6 | 1 | Flucytosine | 1.34 × 10−6 |
CCR4 | Component of the CCR4-NOT transcriptional complex | 5 | 4 | GNF-Pf-2823, GNF-Pf-4583, MMV403679, CBR868 | 6.76 × 10−5 |
ERG3 | C-5 sterol desaturase | 5 | 2 | Miconazole, Posaconazole | 6.76 × 10−5 |
FKS1 | Catalytic subunit of 1,3-beta-D-glucan synthase | 5 | 4 | DDD01027481, CBR113, CBR668, CBR110 | 6.76 × 10−5 |
CDC60 | Cytosolic leucyl-tRNA synthetase | 5 | 2 | CBR668, Tavaborole | |
ROX1 | Heme-dependent repressor of hypoxic genes; | 5 | 3 | Loratadine, MMV665909, TCMDC-124263 | 6.76 × 10−5 |
PDR3 | Transcriptional activator of the pleiotropic drug-resistance network | 5 | 3 | Lapatinib, MMV665794, CBR110 | 6.76 × 10−5 |
OSH3 | Member of an oxysterol-binding protein family | 5 | 1 | Posaconazole | 6.76 × 10−5 |
CSG2 | Endoplasmic reticulum membrane protein | 4 | 2 | GNF-Pf-1618, KAAA726 | 4.76 × 10−2 |
ELO2 | Fatty acid elongase | 4 | 2 | Doxorubicin, MMV667491 | 4.76 × 10−2 |
TUP1 | General repressor of transcription | 4 | 1 | Diethylstilbestrol | |
RPO21 | RNA polymerase II largest subunit B220 | 4 | 4 | Lapatinib, MMV007181, MMV1469689, CBR110 | 4.76 × 10−2 |
SUR2 | Sphinganine C4-hydroxylase | 4 | 1 | MMV667491 | 4.76 × 10−2 |
VMA16 | Subunit c” of the vacuolar ATPase | 4 | 4 | Lapatinib, MMV019017, MMV396736, MMV665882 | 4.76 × 10−2 |
PAN1 | Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p | 4 | 2 | Hygromycin B, KAE609 | 4.76 × 10−2 |
