Fig. 7: pY1062-Ret is activated in human colon, and other human solid tumors. | Communications Biology

Fig. 7: pY1062-Ret is activated in human colon, and other human solid tumors.

From: Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo

Fig. 7

a Y1062 phosphorylation of Ret (pRet) in the colon of WT (N=10), dysplastic tubulous adenoma (N = 10), early invasive intra-mucosal adenocarcinoma (N = 10) and invasive (sub-mucosa and beyond) (N = 10) adenocarcinoma of variable grade (N = 10). b Level of activation of pRet as a function of the tumorous grade (N = 10 by stage). Error bars: standard deviation. c pRet in adenocarcinoma invasive primary tumors of pancreas (N = 71), ovary (N = 101), lung (N = 31), endometrium (N = 31), prostate (N = 31), uveal (N = 61), head and neck (N = 61), breast (N = 61), and cervix malignant (N = 51) tumors. All WT controls are N = 10 (see adapted statistical analysis procedure in methods). Numbers correspond to the phosphorylation level order of magnitude in its predominant subcellular location. Scores in black: p < 0.01, in yellow: p = 0.25 tendency, in red: data heterogeneity prevents statistical analysis.

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