Fig. 2: Fusion detection by breakpoint clustering. | Communications Biology

Fig. 2: Fusion detection by breakpoint clustering.

From: PacBio long-read amplicon sequencing enables scalable high-resolution population allele typing of the complex CYP2D6 locus

Fig. 2

Violin plots overlaid with jitter plots show the distribution of chimeric/fusion read breakpoints for a set of samples selected for illustrative purposes. Chimeric breakpoints are expected to a have a relatively uniform distribution over the length of the amplicon, while true gene fusions should be concentrated within a narrow region. Fusions are called when a sufficient density of breakpoints is detected (see “Methods” and source code for full details).

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