Fig. 3: Frequency and activity of CYP2D6 alleles in the Solomon Islands cohort. | Communications Biology

Fig. 3: Frequency and activity of CYP2D6 alleles in the Solomon Islands cohort.

From: PacBio long-read amplicon sequencing enables scalable high-resolution population allele typing of the complex CYP2D6 locus

Fig. 3

a Frequency of CYP2D6 alleles identified in the Solomon Islands cohort (n = 355), colored by CYP2D6 functional status from the “CYP2D6 Allele Functionality Table” (PharmGKB). Alleles prefixed with “N” represent novel alleles identified in this study that contain variants that are likely to impact protein function (VEP MODERATE and HIGH impact), full allele definitions are available in Supplementary Data 5. b Assigned metabolizer status of individuals in the Solomon Islands cohort (n = 355). In the case an individual contains one or more alleles with unknown function (“?”), the minimum metabolizer status is calculated based on the alleles present with known function.

Back to article page