Fig. 4: Nocturnal polyuria is improved by treatment with an NCC inhibitor (HCTZ), but not by ENaC inhibitor treatment (amiloride). | Communications Biology

Fig. 4: Nocturnal polyuria is improved by treatment with an NCC inhibitor (HCTZ), but not by ENaC inhibitor treatment (amiloride).

From: Dietary salt with nitric oxide deficiency induces nocturnal polyuria in mice via hyperactivation of intrarenal angiotensin II-SPAK-NCC pathway

Fig. 4

a Active period urine volume and inactive period urine volume and DPi in NSD and l-NAME + HSD groups after HCTZ administration (n = 5 mice per group). Statistical analysis was performed using the two-tailed Student’s t-test. b Urinary sodium excretion per day during active (left) and inactive (right) periods (HCTZ-: n = 9, HCTZ+: n = 5 mice per group). Statistical analysis was performed using two-way ANOVA or the two-tailed Student’s t-test. *p < 0.05. c Inactive period urine volume and 24-h urine volume and DPi in NSD and l-NAME + HSD groups after amiloride administration. Data are expressed as the mean ± SEM (amiloride-: n = 6, amiloride+: n = 5). Statistical analysis was performed using the two-tailed Student’s t-test. All data are expressed as the mean ± SEM, *p < 0.05.

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