Fig. 4: PDGF-BB causes PDGFRβ degradation through lysosomal processing in pericytes. | Communications Biology

Fig. 4: PDGF-BB causes PDGFRβ degradation through lysosomal processing in pericytes.

From: Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

Fig. 4

Brain pericytes were treated with PDGF-BB (10 ng/mL) for different lengths of time, then fixed and stained for endo/lysosomal markers. a Representative images of PDGFRβ colabelling with EEA1, Rab5, Rab7 and LAMP1. Scale bar = 50 μm, inset = 10 μm. Quantification of PDGFRβ puncta colocalised with b EEA1, c Rab5, d Rab7 and e LAMP1. n = 5, one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001 vs vehicle control, #p < 0.05, ##p < 0.01, ###p < 0.001 vs PDGF-BB-treated.

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