Fig. 5: Rank of spike protein amino acid substitutions.
From: Statistical modeling of SARS-CoV-2 substitution processes: predicting the next variant

Ranking was performed by our prediction model on 13,544 possible non-synonymous amino acid substitutions in the spike protein resulting from one nucleotide change. The ranks of the 30 substitutions comprising the Omicron variant (lineage B.1.1.529) are shown. The highlighted substitutions were not part of the training dataset.