Fig. 2: PFKFB3βKO DS high mice demonstrate increased impairment of glucose tolerance and similar insulin- but reduced glucagon-plasma levels relative to PFKFB3WT DS mice. | Communications Biology

Fig. 2: PFKFB3βKO DS high mice demonstrate increased impairment of glucose tolerance and similar insulin- but reduced glucagon-plasma levels relative to PFKFB3WT DS mice.

From: β-cell-specific deletion of PFKFB3 restores cell fitness competition and physiological replication under diabetogenic stress

Fig. 2

a Intraperitoneal glucose-tolerance test (IP-GTT) at nine weeks post onset of high-fat diet (HFD). b Quantification of the area under the curve (AUC) as mg/dl x min in the experimental groups shown in (a) (*p = 0.0286). c Insulin-tolerance test (ITT) at 10 weeks after onset of HFD. d Quantification of the AUC as mg/dl x min in the experimental groups shown in (c). e Fasting-plasma insulin. f Fasting-plasma glucagon. g Fasting C-peptide and (h) fasting-insulin/C-peptide ratio (12 weeks post onset of HFD) (n = 3, n = 4 for PFKFB3βKO DS-independent animals, SEM).

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