Fig. 5: Cluster-7 β-cell subpopulation overlaps with LDHA-positive β-cells with HIF1α signature. | Communications Biology

Fig. 5: Cluster-7 β-cell subpopulation overlaps with LDHA-positive β-cells with HIF1α signature.

From: β-cell-specific deletion of PFKFB3 restores cell fitness competition and physiological replication under diabetogenic stress

Fig. 5

a UMAP plot of cluster distribution of 1,482 pancreatic cells coloured by disease conditions (health and T2D). b UMAP plot of cluster distribution and coloured by cell-type annotations [α-cells (alpha), β-cells (beta), cells with low counts, cells with non-verified identity, acinar cells and ductal cell]. c UMAP plot coloured by unsupervised clusters. d UMAP plot showing LDHA expression. The colour scale represents normalised expression level of the gene. Published sc RNA-Seq in23 was presented in a quantitative way to compare nine identified pancreatic-cell subpopulations in the top differentially expressed genes.

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