Fig. 1: In vivo functions of CRP are evolutionarily conserved.
From: Secretory quality control constrains functional selection-associated protein structure innovation
Acute liver failure (n = 11 mice/group; n = 5 rats/group) and sepsis (n = 8 mice/group; n = 12 rats/group) were induced in wild-type and CRP KO mice (a) or rats (b) by i.p. injection of acetaminophen or LPS. c Human CRP (huCRP) was administrated into wild-type mice with acute liver failure (n = 11 for vehicle; n = 10 for huCRP treatment) or sepsis (n = 10 mice/group). CRP KO aggravated, whereas huCRP administration alleviated both diseases. These results reveal consistent in vivo functional phenotypes of mouse, rat, and human CRP. Data are presented as mean ± SEM; ***p < 0.001, two-tailed Student’s t test, two-sided.
