Table 1 TWAS genes with association to Tourette’s syndrome.
Gene | Method | Tissue | P value | Permutation P value | Z-score |
|---|---|---|---|---|---|
FLT3 | Expression | Dorsolateral prefrontal cortex | 3.04E−06 | 0.00616 | 4.6683 |
FLT3 | Expression | Cortex | 3.24E−06 | 0.01289 | 4.6551 |
FLT3 | Expression | Hippocampus | 7.87E−06 | 0.0108 | 4.4688 |
FLT3 | Expression | Anterior cingulate cortex BA24 | 8.12E−06 | 0.007 | 4.462 |
FLT3 | Expression | Frontal cortex BA9 | 8.30E−06 | 0.0185 | 4.4574 |
FLT3 | Expression | Cerebellum | 1.44E−05 | 0.011 | 4.3382 |
DHRS11 | Expression | Substantia nigra | 2.01E−05 | 0.0153 | 4.26398 |
FLT3 | Expression | Cerebellar hemisphere | 2.43E−05 | 0.0096 | 4.22163 |
ATP6V0A2 | Omnibus | – | 3.70E−05 (Nominally significant) | – | – |
NEB | Omnibus | – | 0.000172 (Nominally significant) | – | – |
MPHOSPH9 | Splicing | Dorsolateral prefrontal cortex | 1.58E−05 | 0.01509 | −4.317536 |
FIP1L1 | Splicing | Dorsolateral prefrontal cortex | 2.55E−05 | 0.00184 | 4.21065 |
CSGALNACT2 | Splicing | Dorsolateral prefrontal cortex | 3.39E−05 | 0.00090 | 4.14582 |
