Fig. 1: Loss-of-function of GSTM2 promoted hepatic fat storage.
From: Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression
a–c GSTM2 mRNA and protein expression in liver samples of 8-week HFD fed mice (n = 3) and 8-week chow diet fed mice (n = 3); *p < 0.05. d–f GSTM2 mRNA and protein expression in liver samples of MCDD fed mice and corresponding control mice; *p < 0.05. GAPDH served as the reference gene. g Haematoxylin and eosin (HE) and Oil red O staining analysis of liver samples of GSTM2 knockout (KO) and control mice; bar = 20 μm. h Hepatic TG concentrations of WT (n = 7) and GSTM2 KO (n = 10) mice were detected; ***p < 0.001. i Oil red O analysis of liver samples of GSTM2 KO and control mice challenged with HFD at 0 d, 5 d, 10 d, 20 d, and 30 d. j Hepatic TG concentrations of WT and GSTM2 KO mice with high-fat diet treatment at 0 d, 5 d, 10 d, 20 d, and 30 d; *p < 0.05. bar, 50 μm.
