Fig. 9: IGF-1 released from embryonically derived macrophages binds to IGF-1R on endothelial cells to activate VEGF expression, leading to endothelial cell proliferation, promoting intestinal microvascular development. Deficient macrophage-derived IGF-1 signaling impairs intestinal microvascular development, thus increasing intestinal susceptibility to NEC. | Communications Biology

Fig. 9: IGF-1 released from embryonically derived macrophages binds to IGF-1R on endothelial cells to activate VEGF expression, leading to endothelial cell proliferation, promoting intestinal microvascular development. Deficient macrophage-derived IGF-1 signaling impairs intestinal microvascular development, thus increasing intestinal susceptibility to NEC.

From: Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development

Fig. 9

EnC endothelial cell(s), IGF-1 insulin-like growth factor, IGF-1R IGF-1 receptor.

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