Fig. 2: There are 44 different subregions that are clustered into six groups with direct input to CeA-CRF neurons. | Communications Biology

Fig. 2: There are 44 different subregions that are clustered into six groups with direct input to CeA-CRF neurons.

From: Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice

Fig. 2

a Representative coronal sections indicating the labeling of monosynaptic inputs and their nested subregions throughout the brain (scale bar: 500 μm). The anatomical abbreviations are shown in Supplementary Tables 1–3. b There are three circles in the Circos map that visualized the connection between the input regions and CeA. The inner layer shows the number of input neurons in 44 anatomical subregions, the middle layer shows the proportion of inputs in each subregion to the total inputs, and the outer layer shows the brain regions in which the subregions reside. The lines in the middle connect the input regions and start region (CeA), and the thickness of each line denotes the proportion of inputs from different brain regions. c The 44 subregions were clustered into six groups according to spearman correlations and hierarchal clustering (average method), and the font colors represent the brain regions in which these input neurons reside. These data suggest that brain regions within the same group play similar roles in specific behaviors and that their proportions may be positively correlated with the numbers of their inputs.

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