Fig. 6: MiR-27a-C mutant suppresses cell migration and inhibits secretion levels of the dopamine transmitter.
From: A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1
a After 21 days of induction, the NPC cells (SOX+ Nestin+) differentiated into neurons (MAP2+Tuj1+), scale bar 400 μm; b, c the expression of Dopamine and GABA by ELISA with three replicates (n = 3); d the image of transwell assay for miR-27a-Ctrl (T allele) and miR-27a-Mutant (C allele) using microscope; scale bar, 1000 μm. e the number of migrating cells with eight views for each group (n = 8). Unpaired t-test was performed in b, c, e between two groups; * indicates the significant difference between C allele and T allele (**, p < 0.01; *, p < 0.05; n.s, not significant, p > 0.05). Data were shown as mean ± SD.
