Fig. 7: Possible mechanism of a functional SNP rs895819 on pre-miR-27a associated with bipolar disorder by targeting NCAM1.
From: A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1
The microRNA located in the intron of the chromosome genome is transcribed by RNA polymerase II to produce mRNA, and the initial microRNA is produced by RNA shearing. The initial transcription miRNA (PriRNA) is then cleaved by Drosha to produce the miRNA precursor (pre-miR-27a), where rs895819 (C/T) is located in the stem-loop region of pre-miR-27a, and finally digested by Dicer to form mature miR-27a. miR-27a-T had significantly higher expression than miR-27a-C in NPCs. The T to C mutation at rs895819 affected the maturation of miR-27a from primary form to precursor form. The expression of miR-27a was inhibited and elevated its target gene expression of NCAM1. It is hypothesized that upregulation of NCAM1 might suppress the cell migration and dopamine expression levels and thus result in the bipolar disorder.
