Fig. 2: Ion and water flux through the mGIRK2wv (top) and mGIRK2wt (bottom) SF over simulation time.
From: A selectivity filter mutation provides insights into gating regulation of a K+ channel
a Representative snapshots of ion and water flux through the SF. mGIRK2wv is colored blue, while mGIRK2wt is colored green. The SF is depicted in cartoon representation with the backbone oxygens of the SF residues indicated as red sticks. K+ ions are represented as pink spheres, while Na+ ions are represented as smaller, light blue spheres. Water molecules are shown in a ball-and-stick representation. b K+ (purple) and Na+ ions (blue) flux observed in runs with mGIRK2wv and mGIRK2wt. Each line displays the position of one ion on the z-axis over simulation time. The positions of the backbone oxygens of the SF residues, which frame the canonical ion binding sites S0–S4, are shown in black. c Presence of water in the mGIRK2wv and mGIRK2wt. Each line displays the position of one water molecule on the z-axis over simulation time. The positions of the backbone oxygens of the SF residues are shown in black.
