Fig. 3: Macrophage numbers are linked to glycemic control.
From: Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity
Wild-type mice were fed a coconut-based HFD for 2 months (m) and treated with the CSF1R inhibitor BLZ945 or its vehicle (vehicle n = 5: black circles, 50 µg/g n = 4: light red rhombus, 100 µg/g n = 4: light red triangles, 200 µg/g n = 5: dark red triangles): a Intraperitoneal glucose tolerance test (IPGTT), fasting blood glucose, insulin and insulin tolerance test (ITT). b Fold change of colonic macrophages (c-Macs). c–e Representative flow cytometry plots and fold change of peritoneal macrophages (small: SPM/ large: LPM) (c), microglia (d), and adipose tissue macrophages (ATMs) (e). Statistical data are expressed as mean ± SEM. Data are representative of one (a–e), with each data point representing an individual mouse. *p < 0.05, **p < 0.01, ***p < 0.001, unpaired Mann–Whitney U test with two-tailed distribution.
