Fig. 9: Expression landscape of genes containing tandem GATA motifs in ChIP-Seq peak regions. | Communications Biology

Fig. 9: Expression landscape of genes containing tandem GATA motifs in ChIP-Seq peak regions.

From: Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding

Fig. 9

a GATA2-binding motif in ChIP-Seq peak regions in the GATA2 ChIP-Seq dataset of murine bone marrow lineage-negative cells. b Tandem GATA motifs were used to search ChIP-Seq peak regions containing tandem GATA motifs. Motifs are arranged in ascending order according to the E-value. The right panel shows the distance distributions between ChIP-Seq peak summits and the center of the motifs with color-matched lines. c–e Dot plots for the expression of genes containing the tandem GATA motif(s) in bone marrow LSK cells of 5- to 6-month-old mice. Genes commonly found in two datasets (c), found in the ENCODE dataset (d), and found in the ChIP-Atlas dataset (e) are shown. Tandem GATA motif types found in the ChIP-seq peaks in individual genes are shown. f Dot plots for the expression of genes harboring only a single GATA motif(s) in their proximity in bone marrow LSK cells of 5- to 6-month-old mice. *p < 0.05. Numbers of mice are indicated in the figure.

Back to article page