Fig. 1: Selective neural ERα deletion. | Communications Biology

Fig. 1: Selective neural ERα deletion.

From: Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice

Fig. 1

a. Representative PCR analyses performed on ovaries and brains from control (ERαfl/fl) and mutant females (ERαNesCre). The upper panels show the presence of the floxed ERα allele (881 bp) in the ovaries of both genotypes and in the brain of controls, and the deleted allele (223 bp) in the brain of mutant females expressing the Cre-recombinase in the lower panels. DNA size markers at 100 bp increments are shown in the left column of the four panels. b, c Levels of ERα mRNA normalized to Gapdh levels in the ovary, cortex, hippocampus (HPC) and hypothalamus (HPT) of females (b), or in the testis, cortex, HPC, and HPT of males (c). Data are means ± S.E.M. of three mice per genotype (*p < 0.05, **p < 0.01 versus controls).

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