Fig. 4: Expression of novel candidate genes in the cochlea and utricle during mouse development.
From: Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes
a–f RNA sequencing data of hair cells and surrounding cells from the cochleae and utricles of mice at four developmental stages: E16, P0, P4, and P7 are presented for the mouse orthologs of six novel candidate genes104: Ccdc141 (a), Dnah11 (b), Inpp4b (c), Myo19 (d), Pax8 (e), Sox9 (f). All genes show expression in the inner ear hair cells. Data are presented as normalized RNA-seq counts. g–l Expression of novel candidate genes in spiral and vestibular ganglion neurons of the inner ear during mouse development at six developmental stages: E12, E13, E16, P0, P06, and P15105. Expression is presented for Ccdc141 (g), Dnah11/ Dnahc11 (h), Inpp4b (i), Myo19 (j), Pax8 (k), and Sox9 (l) with all genes showing expression in the spiral and vestibular ganglion of the inner ear during development. Expression microarray data is presented by the perfect match and mismatch probe differences (PM/MM). Data for (a–l) were obtained from SHIELD (Shared Harvard Inner-Ear Laboratory Database).
