Table 3 Dynamic Mean Field model parameters.

From: Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness

Parameter

Symbol

Value

External current

I0

0.382 nA

Excitatory scaling factor for I0

WE

1

Inhibitory scaling factor for I0

WI

0.7

Local excitatory recurrence

w+

1.4

Excitatory synaptic coupling

JNMDA

0.15 nA

Threshold for F (In(E))

Ithr(E)

0.403 nA

Threshold for F (In(I))

Ithr(I)

0.288 nA

Gain factor of F (In(E))

gE

310 nC−1

Gain factor of F (In(I))

gI

615 nC-1

Shape of F (In(E)) around Ithr(E)

dE

0.16 s

Shape of F (In(I)) around Ithr(I)

dI

0.087 s

Excitatory kinetic parameter

\(\gamma\)

0.641

Amplitude of uncorrelated Gaussian noise vn

\(\sigma\)

0.01 nA

Time constant of NMDA

\({\tau }_{{NMDA}}\)

100 ms

Time constant of GABA

\({\tau }_{{{GABA}}_{A}}\)

10 ms