Table 2 Top SNPs (P < 5E−8) associated with serum copper levels in the GWAS meta-analysis.

Metals	SNP	CHR	POS (hg19)	Gene	Function	EA	NEA	EAF	FAMHES				MEWHC				Meta (fixed-effect)
Metals	SNP	CHR	POS (hg19)	Gene	Function	EA	NEA	EAF	BETA	SE	P	N	BETA	SE	P	N	BETA	SE	P	N	Q	I²
SCLs	rs671	12	112241766	ALDH2	exonic	A	G	0.252	−0.226	0.038	4.52E−09	1798	−0.157	0.062	1.15E−02	685	−0.207	0.033	2.21E−10	2483	0.350	0
	rs35691438	3	148940672	CP(+0.84 kb)	upstream	C	T	0.325	0.175	0.035	8.29E−07	1798	0.225	0.064	4.65E−04	685	0.187	0.031	1.63E−09	2483	0.497	0

Abbreviations: SCLs serum copper levels, SNP single-nucleotide polymorphism, CHR chromosome, Function functional consequence on the gene, POS position, EA effect allele, NEA non-effect allele, EAF effect allele frequency, N the sample size of the genome-wide association studies or meta-analysis; Q p-value for Cochran’s Q statistic, I² heterogeneity index (0−100 scale), FAMHES the Fangchenggang Area Male Health and Examination Survey, MEWHC the manganese-exposed workers healthy cohort, Meta meta-analysis of FAMHES and MEWHC.

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