Table 4 Significant robust results of the third round two-sample Mendelian randomization analyses.

From: Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans

Exposure

Outcome

SNPs

IVW

MR-Egger

WM

MR-RAPS

   

OR (95% CI)

P value

Power

Cochran Q statistics (df)

P value

OR (95% CI)

P value

Power

Intercept (Se)

P value

Cochran Q statistics (df)

P value

OR (95% CI)

P value

Power

OR (95% CI)

P value

Power

ECLs

Carpal tunnel syndrome

12

1.041 (1.007 1.075)

0.018

0.62

6.792 (11)

0.816

1.024 (0.968 1.083)

0.426

0.27

0.005 (0.007)

0.507

6.318 (10)

0.788

1.033 (0.988 1.080)

0.153

0.45

1.042 (1.005 1.080)

0.024

0.64

Compression fracture

12

0.841 (0.748 0.945)

0.004

0.79

5.706 (11)

0.892

0.862 (0.668 1.113)

0.283

0.67

−0.006 (0.026)

0.831

5.658 (10)

0.843

0.807 (0.693 0.941)

0.006

0.92

0.838 (0.740 0.949)

0.005

0.81

  1. Abbreviations: ECLs erythrocytes copper levels, MR Mendelian randomization, SNPs number of single-nucleotide polymorphism used as instrumental variables, IVW inverse-variance weighted, WM weighted median, MR-RAPS Mendelian randomization using the robust adjusted profile score, OR odds ratio.
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