Fig. 1: Spontaneous pancreatitis develops in NEMOΔCol1a2 mice after long-term NEMO inhibition. | Communications Biology

Fig. 1: Spontaneous pancreatitis develops in NEMOΔCol1a2 mice after long-term NEMO inhibition.

From: Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Fig. 1

a Scheme of treatment with tamoxifen diet (400 mg/kg) for 18 weeks. b Body weight changes during the 18 weeks of treatment period. Mean±SD (NEMOWT: n = 9; NEMOΔCol1a2: n = 8). Area under the curve was compared. c Spontaneous pancreatitis and infiltration of immune cells observed in NEMOΔCol1a2 pancreata. Scale bar: 100 µm. d Staining of CD45 and αSMA indicated an increase in activated pancreatic stellate cells at area where abundant immune cells were present. Scale bar: 50 µm. e, f Circulating IgM, IgG and ANA levels measured by ELISA on serum samples (NEMOWT: n = 6; NEMOΔCol1a2: n = 5). Whiskers: Min to Max. T-test (two-tailed): *p < 0.05; ***p < 0.001. All n numbers represent biological replicates.

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