Fig. 6: Enrichment of autoimmune gene signatures in NEMOΔCol1a2 pancreata resembling the AIP patients. | Communications Biology

Fig. 6: Enrichment of autoimmune gene signatures in NEMOΔCol1a2 pancreata resembling the AIP patients.

From: Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Fig. 6

DNA microarray performed on pancreatic samples from NEMOWT and NEMOΔCol1a2 mice from the 3-week time point. a Heatmap illustrating genes from the “GO Leukocyte Migration” gene set. b GSEA performed on the microarray results from the pancreatic samples of NEMOΔCol1a2 and NEMOWT mice (n = 3). c GSEA analysis of microarray data from AIP patients (n = 4) using AlCP patients (n = 5) as a reference. d Venn diagrams showing the common GSEA enriched gene sets from the KEGG and Hallmark gene set database (FDR ≤ 0.25). NES Net enrichment score, FDR False discovery rate. All n numbers represent biological replicates.

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