Fig. 7: NEMOΔCol1a2 mice demonstrate an impaired recovery after pancreatitis. | Communications Biology

Fig. 7: NEMOΔCol1a2 mice demonstrate an impaired recovery after pancreatitis.

From: Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Fig. 7

a NEMOΔCol1a2 and NEMOWT mice injected with tamoxifen and caerulein were studied over 18 weeks. b Pancreatic histology showing a complete recovery in the NEMOWT group, while the NEMOΔCol1a2 pancreata still displayed inflammation, fibrosis and structures of metaplastic ductal lesions. Scale bar: 100 µm. c Expression of pro-fibrogenic genes and eosinophil markers analyzed by qPCR (n ≥ 4). d Siglec-F staining showing the presence of eosinophils in the pancreata of NEMOΔCol1a2 mice (18 weeks). Scale bar: 100 μm. e Ratio of pancreatic weight to the body weight (n ≥ 4). Whiskers: Min to Max. T-test (two-tailed): *p < 0.05; **p < 0.01; ***p < 0.001. Mann–Whitney (two-tailed): #p < 0.05. All n numbers represent biological replicates.

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