Fig. 8: Major transcriptomic changes and pathway alterations are found primarily at 6 months with high tau inclusion density. | Communications Biology

Fig. 8: Major transcriptomic changes and pathway alterations are found primarily at 6 months with high tau inclusion density.

From: Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice

Fig. 8

a Heatmap shows hierarchical clustering of major gene expression changes between nTg and tau SPAM mice at 2, 4, and 6 months. b Volcano plot shows 473 differentially expressed genes between 6-month-old tau SPAM and nTg mice. c Top-ten significantly altered genes in tau SPAM mice based on fold change are listed in a table. d Major gene ontology enrichment and significant pathways are altered in tau SPAM mice, including lipid metabolism, proteostasis and cell death, synaptic transmission, inflammatory response, and mitochondrial processes.

Back to article page