Fig. 3: Relative power differences by cortical region or resting-state network.

Bar plots represent 5% FDR corrected pairwise contrasts of model estimates of log relative power between FXS (n = 70) and control (n = 71) participants. For region plots, left and right of individual bars correspond to the right and left hemispheres, respectively. Positive t-values indicate that log relative power estimates in FXS are greater than those in control. a Sex-matched group differences in log relative power by cortical region. Males with FXS demonstrate region-specific increases in gamma power compared to controls with sparing of prefrontal regions. b Sex-matched group differences in log relative power across RSNs. A significant increase in theta and gamma power, as well as a decrease in alpha power, were observed across cognitive and sensory RSNs of males with FXS. Compared to control females, females with FXS had only modest changes in RSNs including similar gamma levels in visual and auditory networks. Obligate mosaicism in Fmr1 in females with full mutation FXS may attenuate EEG alterations. c We explored sex differences in relative power within the FXS group by region and RSN. Positive t-values indicate that log relative power estimates in males with FXS are greater than in females with FXS. There were fewer differences between males and females with FXS than in control comparisons, except for decreased alpha and that gamma activity remained elevated in most regions and all RSNs in males. Resting-state network abbreviations: DMN default mode network, DAN dorsal attention network, SAN salient affective network, VIS visual attention network, AUD auditory network.