Table 1 Lead variants at the 15 loci not previously reported to be associated with hearing loss in GWAS.
Position | rsID | OR (LCI, UCI) | p-value | AAF | nSNPs | Nearest Gene | Direction |
|---|---|---|---|---|---|---|---|
10:78760556:T:C | rs11596052 | 0.959 (0.947, 0.970) | 7.14E−12 | 0.2162 | 94 | ZMIZ1 | +−−−− |
12:109460927:A:G | rs1558804 | 1.033 (1.023, 1.044) | 4.11E−11 | 0.4468 | 620 | KCTD10 | −++++ |
1:88282464:G:A | rs475788 | 1.036 (1.024, 1.047) | 1.56E−10 | 0.7145 | 462 | PKN2 | −++++ |
23:152898837:T:C | rs186256023 | 1.082 (1.056, 1.109) | 3.14E−10 | 0.0315 | 16 | ZNF185 | +++−? |
21:42388983:C:T | rs45598239 | 1.070 (1.048, 1.093) | 4.05E−10 | 0.0549 | 18 | TMPRSS3 | +++++ |
18:6678716:T:A | rs8090563 | 1.031 (1.021, 1.042) | 4.29E−10 | 0.4901 | 210 | ARHGAP28 | +++++ |
20:62819980:C:T | rs61734651 | 1.062 (1.041, 1.083) | 1.60E−09 | 0.0654 | 57 | COL9A3 | +++++ |
1:205751355:G:A | rs823116 | 0.971 (0.961, 0.980) | 1.99E−09 | 0.5493 | 209 | NUCKS1 | +−−−− |
23:20054286:C:T | rs7055595 | 1.033 (1.022, 1.044) | 2.44E−09 | 0.2007 | 488 | MAP7D2 | ++++? |
11:69208057:T:C | rs7926098 | 1.030 (1.020, 1.041) | 5.43E−09 | 0.6182 | 204 | TPCN2 | −++−+ |
13:20186225:A:T | rs117887149 | 1.114 (1.073, 1.156) | 1.40E−08 | 0.0178 | 10 | GJB2 | +++−+ |
17:81711135:C:T | rs62077192 | 1.140 (1.089, 1.193) | 1.55E−08 | 0.0117 | 92 | SLC25A10 | +++−+ |
8:73332501:T:C | rs4738323 | 1.035 (1.023, 1.048) | 2.59E−08 | 0.1972 | 42 | RDH10 | −++++ |
16:55456852:T:A | rs17300627 | 0.967 (0.955, 0.978) | 3.88E−08 | 0.2034 | 105 | MMP2 | +−−−− |
23:116435671:G:A | rs3788766 | 1.025 (1.016, 1.034) | 4.35E−08 | 0.6386 | 66 | SLC6A14 | +++−? |
