Fig. 4: Tecrl deficiency significantly suppressed mitochondrial respiration.
From: TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes
a, b The cardiac ultrastructure of the mice was examined by TEM. Representative image and quantitative analysis of cardiac ultrastructure of the WT and Tecrl KO mice at the age of 8 weeks. Magnification is 6700 x, scale bar = 1 μm (n = 4). c, d Measurements of OCR and respective quantitative analysis of cardiomyocytes isolated from WT and Tecrl KO mice (WT, n = 34, Tecrl KO, n = 32). e, f Representative image and quantitative analysis of DHE staining. The WT and Tecrl KO mice tissues were both measured at the age of 8 weeks (n = 6). g, h Representative image and quantitative analysis of DHE staining in primary neonatal cardiomyocytes (n = 7). i, j Representative image and quantitative analysis of Mitosox staining in primary neonatal cardiomyocytes (n = 4). FCCP, trifluoromethoxy carbonyl cyanide phenylhydrazone. Values are mean ± SE. P < 0.05 was considered significant.
