Fig. 7: Overexpression of TECRL can induce mitochondrial respiration in hiPSC-CMs.
From: TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes
a, b Representative immunoblotting images and quantification of the expression of FAS, MFN2, and TECRL of hiPSC-CMs following TECRL overexpression (n = 6). c Representative images of co-immunoprecipitation of TECRL and ATPB (n = 3). d, e Measurements of OCR and respective quantitative analysis in hiPSC-CMs (n = 12). f Representative images of Cyc and AIF colocalization with Tom 20 in hiPSC-CMs (n = 6). Scale bar = 10 μm. g Cyc and AIF released from the mitochondria into the cytoplasm were analyzed by western blotting. VDAC1 was used as a loading control for mitochondria gradients. GAPDH was used for cytosolic gradient (n = 4). Values are mean ± SE. P < 0.05 was considered significant.
