Fig. 3: Associations of hair mercury level with regional white matter volume (rWMV)(Nā=ā920).

Greater hair mercury level was significantly associated with lower rWMV in widespread white matter areas. Colored bars indicate TFCE scores. TFCE score is unit-free and reflects both voxelās height and the sum of the spatially contiguous voxels supporting it; therefore, it reflects both the strength and extent of effects. All results are overlaid on a āsingle-subject T1ā SPM8 image. a Regions with significant results. The results shown were obtained using a threshold Pā<ā0.05, corrected for multiple comparisons based on 5000 permutations using the TFCE score. b A partial residual plot with the trend line depicting the associations between residuals of mean rWMV in the largest significant cluster and the residuals of the logarithms of hair mercury levels with other confounding factors controlled.