Fig. 7: The elevated plasma exosomal APN level is independently related to a higher risk of poor outcomes. | Communications Biology

Fig. 7: The elevated plasma exosomal APN level is independently related to a higher risk of poor outcomes.

From: Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell

Fig. 7

a Compared with day 0 admission of ICU plasma exosomal APN levels of patients with sepsis-induced ALI decreased at the day 3 in survivors (*P < 0.05, no change observed in non-survivors. b APN expression levels in plasma exosomes were higher in non-survivors compared with those in survivors on the day 3. c The relation between plasma exosomal APN levels and SOFA score. d The ROC curve for individual APN expression level in the plasma exosome of patients on the day 3 to separate good (survivors) outcomes from poor (non-survivors) outcomes during 2 months. e The subgroup of high plasma exosomal APN level was more probable to suffer poor outcomes than the subgroup of low exosomal APN after treatment in ICU (69% vs. 31%). f A high plasma exosomal APN level correlated significantly with an increased mortality rate in patients with severe sepsis ALI/ARDS for 2 months (P = 0.001).

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